Our Research Publications

Updated August 2025

Title Authors Year Journal Link to Article Intended Audience Purpose
Assessing the Rationale and Effectiveness of Frozen Plasma Transfusions: An Evidence-based Review Tinmouth A 2016 Hematol Oncol Clin North Am View Researchers Clinical research
CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fc? Receptor– and Complement Receptor 3–Dependent Mechanisms Amash A, Wang L, Wang Y, Bhakta V, Fairn GD, Hou M, Peng J, Sheffield WP, Lazarus AH 2016 J Immunol View Researchers Basic research
Coagulation factor concentrates Poon MC 2016 Clinical Guide to Transfusion View Health care providers Other
Heterogeneity in Studies of Mesenchymal Stromal Cells to Treat or Prevent Graft-versus-Host Disease: A Scoping Review of the Evidence Rizk M, Monaghan M, Shorr R, Kekre N, Bredeson CN, Allan DS 2016 Biol Blood Marrow Transplant View Researchers Basic research
Platelet transfusion reactions do not occur more often in recipients transfused with apheresis versus buffy coat platelet concentrates Cserti-Gazdewich C, Escorcia A, Pendergrast J, Lieberman L, Skeate R, Lin Y, Callum J 2016 Transfusion View Researchers Clinical research
The Ottawa criteria for the appropriate use of perioperative blood transfusions in liver resection using the RAND/UCLA appropriateness method. Bennett S, Fergusson D, Tinmouth A, McIsaac D, Pawlik T, Hebert P, Mcintyre L, Karanicolas P, Barkun J, Turgeon-Fournier A 2016 Can J Surg View Health care providers Clinical research
Transfusion of fresher vs older red blood cells in hospitalized patients: a systematic review and meta-analysis Alexander PE, Barty R, Fei Y, Vandvik PO, Pai M, Siemieniuk RA, Heddle NM, Blumberg N, McLeod SL, Liu J, Eikelboom JW, Guyatt GH 2016 Blood View Researchers Clinical research
Using simulation for strategic blood supply chain design in the Canadian prairies Blake J, McTaggart K 2016 Proceedings of the 6th International Conference on SIMULTECH View Blood operators New or improved product or process
A randomized controlled trial comparing the outcome of critically ill adults who received fresher vs. older red cells units Lacroix J, Hébert PC, Fergusson DA, Tinmouth A, Walsh T, Stanworth S, Campbell H, Boyd J, Burrows H, Hemmatapour S, on behalf of the Canadian Critical Care Trials Group 2016 ISBT Sci Ser View Health care providers Clinical research
Changing the 30-min Rule in Canada: The Effect of Room Temperature on Bacterial Growth in Red Blood Cells Ramirez-Arcos S, Kou Y, Ducas É, Thibault L 2016 Transfus Med Hemother View Blood operators Benchmarking and standard setting
Difficulties in establishing the diagnosis of immune thrombocytopenia: An agreement study Salib M, Clayden R, Clare R, Wang G, Warkentin TE, Crowther MA, Lim W, Nazi I, Kelton JG, Arnold DM 2016 Am J Hematol View Researchers Clinical research
Effect of short-term vs. long-term blood storage on mortality after transfusion Heddle NM, Cook RJ, Arnold DM, Liu Y, Barty R, Crowther MA, Devereaux P, Hirsh J, Warkentin TE, Webert KE 2016 N Engl J Med View Health care providers Clinical research
Mouse Models for Immune-Mediated Platelet Destruction or Immune Thrombocytopenia (ITP) Neschadim A, Branch DR 2016 Curr Protoc Immunol View Researchers Basic research
ResearchUnit: Data mining: digging for deeper understanding of blood components and transfusion outcomes Heddle NM, Acker JP 2016 Blood.ca website View Other Other
Strain-promoted azide-alkyne cycloaddition for protein-protein coupling in the formation of a bis-hemoglobin as a copper-free oxygen carrier Singh S, Dubinsky-Davidchik IS, Kluger R 2016 Org Biomol Chem View Researchers Basic research
AABB Committee Report: reducing transfusion-transmitted cytomegalovirus infections AABB Clinical Transfusion Medicine Committee, Heddle NM, Boeckh M, Grossman B, Jacobson J, Kleinman S, Tobian AAR, Webert K, Wong ECC, Roback JD 2016 Transfusion View Blood operators Clinical research
Best practices in the differential diagnosis and reporting of acute transfusion reactions Heddle N, Hillis C, Shih A 2016 Internat J Clin Transfus Med View Health care providers Clinical research
Fetal and neonatal alloimmune thrombocytopenia Zdravic D, Yougbare I, Vadasz B, Li C, Marshall AH, Chen P, Kjeldsen-Kragh J, Ni H 2016 Semin Fetal Neonatal Med View Researchers Basic research
Immune Globulin Products Nahirniak S, Lazarus A 2016 Clinical Guide to Transfusion View Health care providers Other
Neurological PRESentations in Sickle Cell Patients Are Not Always Stroke: A Review of Posterior Reversible Encephalopathy Syndrome in Sickle Cell Disease Solh Z, Taccone MS, Marin S, Athale U, Breakey VR 2016 Pediatr Blood Cancer View Health care providers Clinical research
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion Carson JL, Stanworth SJ, Roubinian N, Fergusson DA, Triulzi D, Doree C, Hebert PC 2016 Cochrane Database Syst Rev View Health care providers Clinical research
Validation of administrative database codes for acute kidney injury in kidney transplant recipients Molnar AO, van Walraven C, McArthur E, Fergusson D, Garg AX, Knoll G 2016 Can J Kidney Health Dis View Regulators New or improved product or process
Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia Kapur R, Aslam R, Kim M, Guo L, Ni H, Segel GB, Semple JW 2016 Platelets View Researchers Basic research
An evaluation of overall effectiveness and treatment satisfaction with intravenous immunoglobulin among patients with immune thrombocytopenia Sholapur NS, Hamilton K, Butler L, Heddle NM, Arnold DM 2016 Transfusion View Researchers Clinical research
High-dose dexamethasone compared with prednisone for previously untreated primary immune thrombocytopenia: a systematic review and meta-analysis Mithoowani S, Gregory-Miller K, Goy J, Miller MC, Wang G, Noroozi N, Kelton JG, Arnold DM 2016 Lancet Haematol View Researchers Clinical research
Molecular immunohaematology round table discussions at the AABB Annual Meeting, Anaheim 2015 Flegel WA, Castilho L, Heaton WA, Keller MA, Klapper EB, Lane WJ, Pirenne F, Shehata N, Stack G, St-Louis M, Tormey CA, Wagner FF, Waxman DA, Denomme GA 2016 Transfusion View Health care providers Clinical research
Platelet transfusion therapy in sub-Saharan Africa: bacterial contamination, recipient characteristics, and acute transfusion reactions Hume HA, Ddungu H, Angom R, Baluku H, Kajumbula H, Kyeyune-Byabazaire D, Orem J, Ramirez-Arcos S, Tobian AA 2016 Transfusion View Researchers Basic research
ResearchUnit: United we stand, divided we fall: using monoclonal antibody combinations to improve drug effectiveness Lazarus A 2016 Blood.ca website View Other Other
Stability of Thawed Apheresis Fresh-Frozen Plasma Stored for up to 120 Hours at 1° C to 6° C Sheffield WP, Bhakta V, Yi Q-L, Jenkins C 2016 J Blood Transfus View Researchers Basic research
Temperature stability of Poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at -80°C, 4°C, 25°C and 37°C or pasteurization at 70°C Bian Y, Guo C, Chang T 2016 Artif Cells Nanomed Biotechnol View Researchers Basic research
Triplets with neonatal alloimmune thrombocytopenia due to antibodies against human platelet antigen 1a Solh Z, Breakey V, Murthy P, Smith JW, Arnold DM 2016 Transfusion View Health care providers Clinical research
A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus McCarthy SDS, Majchrzak-Kita B, Racine T, Kozlowski HN, Baker DP, Hoenen T, Kobinger GP, Fish EN, Branch DR 2016 PLoS Negl Trop Dis View Researchers Basic research
Deformability based sorting of red blood cells improves diagnostic sensitivity for malaria caused by Plasmodium falciparum Guo Q, Duffy SP, Matthews K, Deng X, Santoso AT, Islamzada E, Ma H 2016 Lab Chip View Researchers New or improved product or process
Platelets, immune-mediated thrombocytopenias, and fetal hemorrhage Xu XR, Gallant RC, Ni H 2016 Thromb Res View Researchers Basic research
Protein translation occurs in platelet concentrates despite riboflavin/UV light pathogen inactivation treatment Schubert P, Culibrk B, Karwal S, Goodrich RP, Devine DV 2016 Proteomics Clin Appl View Researchers Basic research
Transfusion-related alloimmunization in children: epidemiology and effects of chemotherapy Solh Z, Athale U, Arnold DM, Cook RJ, Foley R, Heddle NM 2016 Vox Sang View Health care providers Clinical research
Alteration of blood clotting and lung damage by protamine are avoided using the heparin and polyphosphate inhibitor UHRA Kalathottukaren MT, Abraham L, Kapopara PR, Lai BFL, Shenoi RA, Rosell FI, Conway EM, Pryzdial ELG, Morrissey JH, Haynes CA, Kizhakkedathu JN 2016 Blood View Researchers Basic research
Detection of bacterial adherence and biofilm formation on medical surfaces Loza-Correa M, Ramirez-Arcos S 2016 Biofilms and implantable medical devices: infection and control View Researchers New or improved product or process
Elevation of C-reactive protein levels in patients with transfusion-related acute lung injury Kapur R, Kim M, Rondina MT, Porcelijn L, Semple JW 2016 Oncotarget View Researchers Basic research
Small molecule ice recrystallization inhibitors mitigate red blood cell lysis during freezing, transient warming and thawing Briard JG, Poisson JS, Turner TR, Capicciotti CJ, Acker JP, Ben RN 2016 Sci Rep View Researchers New or improved product or process
ResearchUnit: Mastering the monocyte monolayer assay Branch D 2016 Blood.ca website View Other Other
RhoA/ROCK signaling contributes to sex differences in the activation of human platelets Schubert P, Coupland D, Nombalais M, Walsh G, Devine DV 2016 Thromb Res View Researchers Basic research
Shining a light on AHG "blind" spot(s) Branch DR, Westhoff CM 2016 Transfusion View Researchers Basic research
Understanding stakeholder important outcomes and perceptions of equity, acceptability and feasibility of a care model for haemophilia management in the US: a qualitative study Lane SJ, Sholapur NS, Yeung CH, Iorio A, Heddle NM, Sholzberg M, Pai M 2016 Haemophilia View Health care providers Other
CD8(+) T cells induce platelet clearance in the liver via platelet desialylation in immune thrombocytopenia Qiu J, Liu X, Li X, Zhang X, Han P, Zhou H, Shao L, Hou Y, Min Y, Kong Z, Wang Y, Wei Y, Liu X, Ni H, Peng J, Hou M 2016 Sci Rep View Researchers Basic research
Platelet transfusion, alloimmunization, and management of platelet refractoriness Zeller M 2016 Clinical Guide to Transfusion View Health care providers Other
Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease Kanias T, Sinchar D, Osei-Hwedieh D, Baust JJ, Jordan A, Zimring JC, Waterman HR, de Wolski KS, Acker JP, Gladwin MT 2016 Transfusion View Researchers Basic research
Thrombolysis by chemically modified coagulation factor Xa Pryzdial ELG, Meixner SC, Talbot K, Eltringham-Smith LJ, Baylis JR, Lee FMH, Kastrup CJ, Sheffield WP 2016 J Thromb Haemost View Researchers Basic research
Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B-regulatory cells Aslam R, Segel GB, Burack R, Spence SA, Speck ER, Guo L, Semple JW 2016 Br J Haematol View Researchers Basic research
The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation Lewis JK, Bischof JC, Braslavsky I, Brockbank KGM, Fahy GM, Fuller BJ, Rabin Y, Tocchio A, Woods EJ, Wowk BG, Acker JP, Giwa S 2016 Cryobiology View Researchers Other