Measurement of heavy metals in donor blood in Canada

Fetal and neonatal exposure to lead has been assocaited with irreversible adverse effects on brain and neural development. There is no reliable threshold for the effect of lead so limiting the exposure is recommended, particularly in vulnerable groups. Some studies have reported that a blood transfusion with a high, yet clinically unapparent levels of lead can significantly increase the blood lead level of apremature infant recipient. This study will investigate where blood transfusion is a considerable source of exposure to heavy metals that requires monitoring.
We will collect a representative corss-section of Canadian donor blood sampels and measure the levels of lead along with two other toxic heavy metals, mercury and cadmium. We will also report the proportion of blood units that contain 'high' levels of these metals. Such data would allow policu makers to assess any necessity of screening blood units for heavy metals before transfusion to vulnerable groups. Further, donors' demographic factors such as age and sex will be correalted to the level of heavy metals. The possible association can be useful for the informed selection of blood units for transfusion to premature inants and or any vulnerable group; providing safer and higher quality products to the benefit of patients.

DEVINE, Dana

Canadian Blood Services

Blood Efficiency Accelerator Program

British Columbia

$29,971