Our Research Publications

Updated November 2023

Title Authors Year Journal Link to Article Intended Audience Purpose
Overcoming the deceptively low viability of CD45+ cells in thawed cord blood unit segments Pasha R, Halpenny M, Pineault N 2019 Vox Sang View Researchers New or improved product or process
The 14-3-3ζ–c-Src–integrin-?3 complex is vital for platelet activation Shen C, Liu M, Xu R, Wang G, Li J, Chen P, Ma W, Mwangi J, Lu Q, Duan Z, Zhang Z, Dahmani FZ, Mackeigan DT, Ni H, Lai R 2020 Blood View Researchers Basic research
Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): Study protocol for an international, multicenter, randomized open-label trial Bégin P, Callum J, Heddle N, Cook R, Zeller MP, Tinmouth A, Fergusson D, Cushing MM, Glesby MJ, Chassé M, Devine DV, Robitaille N, Bazin R, Shehata N, Finzi A, McGeer A, Scales D, Schwartz L, Turgeon AF, Zarychanski R, Daneman N, Carl R, Amorim L, Gabe C, Ellis M, Jamula E, Carruthers J, Duncan J, Lucier K, Armali C, Kron A, Modi D, Auclair M-C, Avram M, Arnold DM 2021 Trials View Researchers Clinical research
Establishment of Transfusion-Relevant Bacteria Reference Strains for Red Blood Cells Prax M, Spindler-Raffel E, McDonald CP, Bearne J, Satake M, Kozakai M, Rojo J, Hanschmann K-MO, Lambrecht B, Grundmann U, O’Flaherty N, Klimek A, Bekeredjian-Ding I, Gathof BS, Störmer M, Süßner S, Renke C, Lee C-k, Knabbe C, Vollmer T, Keil SD, Shipps ME, Wagner SJ, Jentsch U, Mpumlwana X, Cloutier M, Bringmann P, Lu T, Ramirez-Arcos S, Kou Y, Krut O, ISBT Transfusion-Transmitted Infectious Diseases Working Party SoB 2020 Vox Sang View Researchers New or improved product or process
In Vitro Characterization and Metabolomic Analysis of Cold-Stored Platelets Zhao HW, Serrano K, Stefanoni D, D’Alessandro A, Devine DV 2021 J Proteome Res View Researchers Basic research
Pathogen reduction of whole blood: Supplementing fibrinogen partly corrects clot formation in a massive transfusion model Arbaeen AF, Schubert P, Sheffield WP, Devine DV 2021 Transfusion View Researchers New or improved product or process
Transient loss of membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers William N, Acker JP 2020 Cryobiology View Researchers Basic research
Heparin-Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia Antibodies: Fraternal-Not Identical-Twins Warkentin TE 2021 Thromb Haemost View Researchers Clinical research
Vaccine-induced immune thrombotic thrombocytopenia presenting with normal platelet count Page D, Zhu N, Sawler D, Sun HW, Turley E, Pai M, Wu C 2021 Res Pract Thromb Haemost View Researchers Clinical research
External qualification of the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) models for octocog alfa using real patient data Chelle P, Hajducek D, Mahdi M, Young S, Iorio A, Silvertown J, Edginton A 2021 Res Pract Thromb Haemost View Researchers New or improved product or process
In Vitro Effect of Methamphetamine on Proliferation, Differentiation and Apoptosis of Adipose Tissue Stem Cells: In vitro Effect of Methamphetamine Anari L, Mehrabani D, Nasiri M, Zare S, Jamhiri I, Acker J 2022 J Pharm Sci View Researchers Basic research
Characterization of CD41(+) cells in the lymph node Dai L, Uehara M, Li X, LaBarre BA, Banouni N, Ichimura T, Lee-Sundlov MM, Kasinath V, Sullivan JA, Ni H, Barone F, Giannini S, Bahmani B, Sage PT, Patsopoulos NA, Tsokos GC, Bromberg JS, Hoffmeister K, Jiang L, Abdi R 2022 Front Immunol View Researchers Basic research
How do we forecast tomorrow's transfusion? Applying social science approaches to meet tomorrow's transfusion needs: Blood donors and donation Haw J, Holloway K, Goldman M 2023 Transfus Clin Biol View Researchers Ethical, legal & social implications research
Antigen copy number and antibody dose can determine the outcome of erythrocyte alloimmunization inducing either antibody-mediated immune suppression or enhancement in a murine model Wabnitz H, Cruz-Leal Y, Lazarus AH 2023 Transfusion View Researchers Basic research
A monoclonal antibody with anti-D–like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects Yu X, Menard M, Seabright G, Crispin M, Lazarus AH 2015 Transfusion View Researchers Basic research
Amelioration of Murine Passive Immune Thrombocytopenia by IVIg and a Therapeutic Monoclonal CD44 Antibody Does Not Require the Myd88 Signaling Pathway Crow AR, Yu H, Han D, Lazarus AH 2013 PLoS One View Researchers Basic research
CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia Guo L, Kapur R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW 2016 Blood View Researchers Basic research
Clinical Studies of Ex Vivo Expansion to Accelerate Engraftment After Umbilical Cord Blood Transplantation: A Systematic Review Kiernan J, Damien P, Monaghan M, Shorr R, McIntyre L, Fergusson D, Tinmouth A, Allan D 2016 Transfus Med Rev View Researchers Clinical research
Engineering biomaterials surfaces to modulate the host response Yu K, Mei Y, Hadjesfandiari N, Kizhakkedathu JN 2014 Colloids Surf B Biointerfaces View Researchers Basic research
Immunogenicity of murine mPEG-red blood cells and the risk of anti-PEG antibodies in human blood donors Le Y, Toyofuku WM, Scott MD 2017 Exp Hematol View Researchers Basic research
Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution Imran ul-haq M, Lai BF, Chapanian R, Kizhakkedathu JN 2012 Biomaterials View Researchers Basic research
IVIG regulates the survival of human but not mouse neutrophils Schneider C, Wicki S, Graeter S, Timcheva TM, Keller CW, Quast I, Leontyev D, Djoumerska-Alexieva IK, Kasermann F, Jakob SM, Peyta D, Branch D, Cummings J, Kaufmann T, Simon H, Von Gunten S 2017 Sci Rep View Researchers Basic research
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE, Jr., Semple JW 2017 Blood Adv View Researchers Basic research
Non-invasive spectroscopy of transfusable red blood cells stored inside sealed plastic blood-bags Buckley K, Atkins CG, Chen D, Schulze HG, Devine DV, Blades MW, Turner RFB 2016 Analyst View Researchers New or improved product or process
Platelet MicroRNAs: An Overview Dahiya N, Sarachana T, Vu L, Becker KG, Wood WH, Zhang Y, Atreya CD 2015 Transfus Med Rev View Researchers Basic research
Preserving and using germplasm and dissociated embryonic cells for conserving Caribbean and Pacific coral Hagedorn M, Carter V, Martorana K, Paresa MK, Acker J, Baums IB, Borneman E, Brittsan M, Byers M, Henley M, Laterveer M, Leong JA, McCarthy M, Meyers S, Nelson BD, Petersen D, Tiersch T, Uribe RC, Woods E, Wildt D 2012 PLoS One View Researchers Basic research
The immune-stimulation capacity of liposome-treated red blood cells da Silveira Cavalcante L, Branch DR, Duong TT, Yeung RSM, Acker JP, Holovati JL 2017 J Liposome Res View Researchers Basic research
Utility of cross-matched platelet transfusions in patients with hypoproliferative thrombocytopenia: a systematic review Vassallo RR, Fung M, Rebulla P, Duquesnoy R, Saw CL, Slichter SJ, Tanael S, Shehata N, International Collaboration for Guideline Development Implementation Evaluation for Transfusion Therapies Collaborators 2013 Transfusion View Researchers Clinical research
Anti-M Clarke G, Cote J, Lane D 2018 Blood.ca website View Researchers Basic research
ResearchUnit: Modeling risk to ensure safety when considering changes to blood testing O'Brien S 2019 Blood.ca website View Researchers Basic research
Role of von Willebrand factor and ADAMTS-13 in early brain injury after experimental subarachnoid hemorrhage Wan H, Wang Y, Ai J, Brathwaite S, Ni H, Macdonald RL, Hol EM, Meijers JCM, Vergouwen MDI 2018 J Thromb Haemost View Researchers Basic research
The association between platelet transfusions and mortality in patients with critical illness Ning S, Liu Y, Barty R, Cook R, Rochwerg B, Iorio A, Warkentin TE, Heddle NM, Arnold DM 2019 Transfusion View Researchers Clinical research
The impact of red blood cell manufacturing variables on bacterial growth dynamics: a pilot study Ramirez-Arcos S, Kou Y, Cayer M-P, De Grandmont M-J, Girard M, Cloutier M 2019 Vox Sang View Researchers Basic research
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fc? receptor inhibition Norris PAA, Kaur G, Khan R, Zhu G, Ni H, Lazarus AH 2021 Blood View Researchers Basic research
Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing Tremblay T, Branch DR, Loubaki L 2020 Transfusion View Researchers New or improved product or process
Selection and in vitro and in vivo characterization of a Kunitz protease inhibitor domain of protease nexin 2 variant that inhibits factor XIa without inhibiting plasmin Eltringham-Smith LJ, Bhakta V, Sheffield WP 2021 J Biotechnol View Researchers Basic research
Five novel FY null alleles associated with typing discrepancies Vege S, Floch A, Lomas-Frances C, Clarke G, Westhoff CM 2021 Transfusion View Researchers Benchmarking and standard setting
Background incidence rates of hospitalisations and emergency department visits for thromboembolic and coagulation disorders in Ontario, Canada for COVID-19 vaccine safety assessment: a population-based retrospective observational study Nasreen S, Calzavara AJ, Sundaram ME, MacDonald SE, Righolt CH, Pai M, Field TS, Zhou LW, Wilson SE, Kwong JC 2021 BMJ Open View Researchers Clinical research
Plateletworks® as a Point-of-Care Test for ASA Non-Sensitivity Khan H, Jain S, Gallant RC, Syed MH, Zamzam A, Al-Omran M, Rand ML, Ni H, Abdin R, Qadura M 2021 J Pers Med View Researchers New or improved product or process
Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers Blamey G, Van Tassel B, Sagermann E, Stain AM, Waterhouse L, Iorio A 2022 Haemophilia View Researchers Ethical, legal and social implications research
Taking lessons from nature to improve cell therapy cryopreservation Acker J, William N, Coatham M 2023 Cell Gene Ther Insights View Researchers Basic research
Molecular Screening of Blood Donors for Babesia in Tyrol, Austria Bloch EM, Siller A, Tonnetti L, Drews SJ, Spencer BR, Hedges D, Mergenthal T, Weber-Schehl M, Astl M, Patel EU, Gaber M, Schennach H 2023 Transfus Med Hemother View Researchers Clinical research
Characteristics of VITT antibodies in patients vaccinated with Ad26.COV2.S Huynh A, Arnold DM, Michael JV, Clare R, Smith JW, Daka M, Ianosi-Irimie M, McKenzie SE, Kelton JG, Nazy I 2023 Blood Adv View Researchers Clinical research
Donor sex, pre-donation hemoglobin, and manufacturing affect CD71+ cells in red cell concentrates Li W, William N, Acker JP 2023 Transfusion View Researchers Basic research
How do we decide how representative our donors are for public health surveillance? O'Brien SF, Drews SJ, Lewin A, Russell A, Davison K, Goldman M, International Society for Blood Transfusion Transfusion Transmitted Infectious Disease Working Party Surveillance Risk Assessment Policy Sub-group 2022 Transfusion View Researchers Benchmarking and standard setting
GRADE guidance 35: update on rating imprecision for assessing contextualized certainty of evidence and making decisions Schünemann HJ, Neumann I, Hultcrantz M, Brignardello-Petersen R, Zeng L, Murad MH, Izcovich A, Morgano GP, Baldeh T, Santesso N, Cuello CG, Mbuagbaw L, Guyatt G, Wiercioch W, Piggott T, De Beer H, Vinceti M, Mathioudakis AG, Mayer MG, Mustafa R, Filippini T, Iorio A, Nieuwlaat R, Marcucci M, Coello PA, Bonovas S, Piovani D, Tomlinson G, Akl EA 2022 J Clin Epidemiol View Researchers Clinical research
Cold-stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry Zhao HQ, Serrano K, Culibrk B, Chen Z, Devine DV 2022 Transfusion View Researchers New or improved product or process
[Influence of Anticoagulants on Detection of ITP Platelet-Specific Autoantibodies and Relationship of Autoantibody Types with Glucocorticoid Efficacy] Chen Y, Ge J, Ruan M, Zhu L-Y, Zeng Q-S, Xia R-X, Ni H 2015 Zhongguo shi yan xue ye xue za zhi View Researchers Basic research
A platelet cover-up Arnold DM 2013 Blood View Researchers Other
Adoptive-Transfer Effects of Intravenous Immunoglobulin in Autoimmunity Lazarus AH 2010 J Clin Immunol View Researchers Basic research