Transfusion-related Epstein-Barr Virus (EBV) infection among allogeneic stem cell transplant pediatric recipients: A multicenter prospective cohort study (TREASuRE Study)

In many countries, numerous steps are taken to minimize the risk of infection from transfused blood products. However, the risk of transfusion transmitted infections for which testing is not currently performed continues to be a concern. Among these untested infectious agents is Epstein-Barr virus (EBV) which, in the transplant setting, is associated with a malignant tumor of white blood cells. This is an especially serious complication in infants and young children who are exposed to the virus shortly after their transplant. EBV is also associated with many other complications. It is imperative to track the source of virus and find ways to prevent its transmission to patients at risk. We therefore propose to undertake an epidemiological study in children receiving umbilical cord-blood and bone marrow transplants. Our objective is to examine the incidence of post-transplant Epstein-Barr virus infection in these children and its association with blood product transfusion. To do this we have designed a multicenter prospective cohort study involving several sites in Canada and the USA. We will collect data from patient charts to help us determine the level of transfusion-related risk for acquiring Epstein-Barr virus infection. Demonstrating transmission of Epstein-Barr virus via transfusion in these patients may give rise to new policies which in turn may have significant implications with regard to the morbidity and mortality associated with Epstein-Barr virus infection.

TROTTIER, Helen

Hopital Sainte-Justine

Canadian Blood Services-CIHR Partnership Operating Grant Program

Quebec

$519,766